sg 2

ATR inhibition prematurely activates FOXM1, deregulating the S/G 2 transition and leading to early mitosis, underreplicated DNA, and DNA damage. pp couple ber 2 Thus, ATR couples DNA replication with mitosis and preserves genome integrity by enforcing an S/G 2 checkpoint To avoid loss of genetic information, cells must replicate their DNA before mitosis ( 1 )